Revista Brasileira de Hematologia e Hemoterapia Revista Brasileira de Hematologia e Hemoterapia
Hematology,Transfusion and Cell Therapy 2018;40:12-7 DOI: 10.1016/j.bjhh.2017.09.005
Original article
Platelet count response to Helicobacter pylori eradication for idiopathic thrombocytopenic purpura in northeastern Brazil
Alzira Maria de Castro Barbosaa, Rosangela Albuquerque Ribeirob, Cícero Ígor Simões Moura Silvaa, Francisco Will Saraiva Cruza, Orleancio Gomes Ripardo de Azevedoa, Maria Helena da Silva Pitombeirab, Lucia Libanez Campelo Bragaa,,
a Universidade Federal do Ceará (UFC), Fortaleza, CE, Brazil
b Centro de Hematologia e Hemoterapia do Ceará (Hemoce), Fortaleza, CE, Brazil
Received 13 February 2017, Accepted 11 September 2017
Abstract
Background

Several studies have demonstrated that platelet counts in Helicobacter pylori-positive patients with chronic idiopathic thrombocytopenic purpura improved significantly after successful eradication of the infection. However, depending of the geographical region of the study the results have been highly divergent.

Objective

The purpose of this study was to evaluate the effect of H. pylori eradication therapy on platelet count in a cohort of chronic idiopathic thrombocytopenic purpura patients from northeastern Brazil.

Method

H. pylori status was determined in 28 chronic idiopathic thrombocytopenic purpura patients using the rapid urease test and histology. H. pylori-positive patients received standard triple therapy for one week. The effect of the eradication therapy was evaluated using the 13C-urea breath test two to three months after treatment.

Results

The prevalence of H. pylori infection was similar to that found in the general population. Twenty-two patients (78.5%) were H. pylori-positive. Fifteen were treated, 13 (86%) of whom successfully. At six months, 4/13 (30%) displayed increased platelet counts, which remained throughout follow-up (12 months). Platelet response was not associated to mean baseline platelet count, duration of chronic idiopathic thrombocytopenic purpura, gender, age, previous use of medication, or splenectomy.

Conclusions

H. pylori eradication therapy showed relatively low platelet recovery rates, comparable with previous studies from southeastern Brazil. The effect of H. pylori eradication on platelet counts remained after one year of follow-up suggesting that treating H. pylori infection might be worthwhile in a subset of chronic idiopathic thrombocytopenic purpura patients.

Keywords
Helicobacter pylori eradication, Blood platelet, Idiopathic thrombocytopenic purpura
Hematology,Transfusion and Cell Therapy 2018;40:12-7 DOI: 10.1016/j.bjhh.2017.09.005