Revista Brasileira de Hematologia e Hemoterapia Revista Brasileira de Hematologia e Hemoterapia
Rev Bras Hematol Hemoter 2014;36:287-9 DOI: 10.1016/j.bjhh.2014.05.008
Case Report
Transmission of lupus anticoagulant by allogeneic stem cell transplantation
Mira Romany Massoud, Basem M. William??, , Katrina Harrill, Brenda Wimpfheimer Cooper, Marcos de Lima, Alvin H. Schmaier
University Hospitals Case Medical Center, Case Western Reserve University, Cleveland, United States
Received 28 November 2013, Accepted 09 December 2013
Abstract

Passive transmission of autoimmune diseases by allogeneic stem cell transplantation is rare and is ascribed to passive transfer of memory B-cells from donor to recipient. We hereby report a case of transmission of an asymptomatic lupus anticoagulant from a sibling donor to a recipient of transplantation for secondary acute myeloid leukemia. On pre-harvest evaluation, the sibling donor with no history of bleeding or thrombosis was found to have a lupus anticoagulant. After engraftment, the recipient was found to have a new prolonged activated partial thromboplastin time and was subsequently shown to have a lupus anticoagulant on Day +73 after stem cell transplantation. The recipient remained well with no evidence of bleeding, thrombosis, or graft-versus-host disease and was on a stable dose of tacrolimus at the time the lupus anticoagulant was detected. There was no other identifiable trigger for the appearance of a lupus anticoagulant.

Keywords
Allogeneic stem cell transplantation, Lupus anticoagulant, Activated partial thromboplastin time
Rev Bras Hematol Hemoter 2014;36:287-9 DOI: 10.1016/j.bjhh.2014.05.008