Revista Brasileira de Hematologia e Hemoterapia Revista Brasileira de Hematologia e Hemoterapia
Hematology,Transfusion and Cell Therapy 2018;40:43-9 DOI: 10.1016/j.bjhh.2017.08.006
Review article
Can dentists detect multiple myeloma through oral manifestations?
Thaís Miranda Xavier de Almeida, Édila Figuerêdo Feitosa Cavalcanti, Alessandra da Silva Freitas, Roberto José Pessoa de Magalhães, Angelo Maiolino, Sandra Regina Torres,
Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, RJ, Brazil
Recebido 29 Março 2017, Aceitaram 24 Agosto 2017
Abstract
Objective

To review published data on oral manifestations of multiple myeloma.

Methods

An electronic database search was performed of articles published from 1971 to November 2016 in order to identify studies that reported oral manifestations of patients with multiple myeloma. Case reports and case series with oral manifestations of multiple myeloma in English were included in the study. An additional search was performed of the references of the selected articles.

Results

Thirty-seven articles that reported 81 patients with oral manifestations of multiple myeloma were selected: 30 case reports (82%) and seven case series (18%). The most common clinical features in the dental cavity were swelling (65.4%), bone pain (33.3%), paresthesia (27.1%) and amyloidosis lesions (11.1%). Osteolytic lesions detected on imaging exams were reported in the majority of the patients (90.1%) as plasmacytomas or ‘punched-out’ lesions.

Conclusions

Swelling and osteolytic lesions represent the most common clinical and radiographic signs of the jaws relating to multiple myeloma, respectively.

Keywords
Multiple Myeloma, Oral Manifestations, Mouth, Jaws
Hematology,Transfusion and Cell Therapy 2018;40:43-9 DOI: 10.1016/j.bjhh.2017.08.006