Revista Brasileira de Hematologia e Hemoterapia Revista Brasileira de Hematologia e Hemoterapia
Rev Bras Hematol Hemoter 2017;39:32-9 DOI: 10.1016/j.bjhh.2016.09.004
Original article
Comprehensive neuropsychological evaluation of children and adolescents with sickle cell anemia: a hospital-based sample
Samantha Nunes, , Nayara Argollo, Marivania Mota, Camilo Vieira, Eduardo Pond?? de Sena
Universidade Federal da Bahia (UFBA), Salvador, BA, Brazil
Recebido 14 Maio 2016, Aceitaram 12 Setembro 2016
Abstract
Background

Individuals with sickle cell anemia may suffer symptomatic or silent cerebral infarcts leading to neurocognitive complications. This study investigated the cognitive and intellectual performance of children and adolescents with sickle cell anemia.

Methods

The socioeconomic status, clinical aspects and behavioral profile of 15 young individuals with sickle cell anemia were evaluated. The Wechsler Intelligence Scale for Children, the Developmental Neuropsychological Assessment Test, and the Child Behavior Checklist were applied.

Results

Participants with a history of stroke had lower intelligence quotient (IQ) scores. Alterations were found in attention and executive functioning, language, verbal and visual memory, visuospatial processing and sensorimotor skills. These alterations were found both in the children and adolescents who had had a cerebral infarction and in those who apparently had not. In the majority of cases, there were learning difficulties, a history of repeating school years and a need for specialist educational support. The most common additional diagnoses in accordance with the Diagnostic and Statistical Manual of Mental Disorders IV were depressive disorder, anxiety disorder and somatic disorder, as well as conditions associated with physical and psychosocial repercussions of sickle cell anemia.

Conclusion

As sickle cell anemia is considered a progressive cerebral vasculopathy, it is a potential risk factor for neurocognitive and psychosocial development. Therefore, periodic neuropsychological and behavioral evaluations of children and adolescents with sickle cell anemia may represent a useful measure to reduce long-term biopsychosocial repercussions.

Keywords
Anemia, sickle cell, Intelligence tests, Neuropsychological tests, Behavioral disorders, Neurobehavioral manifestations
Rev Bras Hematol Hemoter 2017;39:32-9 DOI: 10.1016/j.bjhh.2016.09.004