Revista Brasileira de Hematologia e Hemoterapia Revista Brasileira de Hematologia e Hemoterapia
Rev Bras Hematol Hemoter 2017;39:301-5 DOI: 10.1016/j.bjhh.2017.05.007
Original article
Lack of association between Kidd blood group system and chronic kidney disease
Tiago Verri Capriolli, Jeane Eliete Laguila Visentainer, Ana Maria Sell, ,
Universidade Estadual de Maringá (UEM), Maringá, PR, Brazil
Recebido 27 Março 2017, Aceitaram 30 Maio 2017
Relacionado:
Rev Bras Hematol Hemoter 2017;39:293-4
Abstract
Background

The Kidd blood group system has three antigens, Jka, Jkb and Jk3, found on red blood cells and on endothelial cells of the inner lining of blood vessels in the renal medulla. These are known as urea transporter B (UT-B). Researchers have found that individuals carrying the Jk(ab−) or Jk-null (UT-B null) phenotypes have a lower urine-concentrating capability and risk of severe renal impairment. This study evaluated the distribution of the Kidd phenotypes in patients with chronic kidney disease and a possible association of Kidd antigens with the development of renal disease.

Methods

Jka and Jkb antigens were phenotyped using the gel column agglutination test (ID-cards Bio-RAD) in 197 patients with chronic kidney disease and 444 blood donors, as the control group. The phenotype and antigen frequencies between patients and controls were evaluated using the Chi-square method with Yates correction and logistic regression after adjustments for gender and age.

Results

No differences were observed between the Kidd phenotypes frequency distribution between patients with chronic kidney disease and blood donors [Jk(ab+)=22.3% and 27.2%; Jk(a+b−)=30.5% and 24.3%; Jk(a+b+)=47.25% and 48.4%, respectively].

Conclusion

The distribution of Kidd phenotypes found in the studied population is expected for Caucasians; Jka and Jkb antigens and phenotypes were not found to be related to susceptibility for chronic kidney disease.

Keywords
Kidd blood group system, Chronic kidney failure, Serotyping, Blood urea nitrogen, Urea transporter
Rev Bras Hematol Hemoter 2017;39:301-5 DOI: 10.1016/j.bjhh.2017.05.007