Revista Brasileira de Hematologia e Hemoterapia Revista Brasileira de Hematologia e Hemoterapia
Rev Bras Hematol Hemoter 2014;36:65-8 DOI: 10.5581/1516-8484.20140016
Oral cancer after prolonged immunosuppression for multiorgan chronic graft-versus-host disease
Renata Lins Fuentes de Araújo, Karine de Fátima Lyko, Vaneuza Araújo Moreira Funke, Cassius Carvalho Torres-Pereira,
Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil
Recebido 10 Junho 2013, Aceitaram 02 Agosto 2013
ABSTRACT

Long-term survivors of hematopoietic stem cell transplantation are recognized as a risk group for malignization. Malignant oral neoplasms are increasingly being reported in the literature as a consequence of lesions of chronic graft-versus-host disease, and prolonged multidrug treatment to control its manifestations. This report describes a 43-year-old patient who, after allogeneic bone marrow transplantation, developed an oral squamous cell carcinoma secondary to the use of azathioprine, cyclosporine, prednisone, and tacrolimus, associated with multiorgan chronic graft-versus-host disease involving the oral mucosa, skin, eyes, and liver. This report aims to discuss the possible role of immunosuppressant therapy for chronic graft-versus-host disease on the development of oral squamous cell carcinoma, and the relevance of a close oral follow-up of patients to detect dysplastic or malignant alterations at an early stage.

© 2014 Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular. Published by Elsevier Editora Ltda. All rights reserved.

Keywords
Mouth neoplasms, Bone marrow transplantation, Leukemia, Myeloid, Graft-versus-host disease
Rev Bras Hematol Hemoter 2014;36:65-8 DOI: 10.5581/1516-8484.20140016