Revista Brasileira de Hematologia e Hemoterapia Revista Brasileira de Hematologia e Hemoterapia
Rev Bras Hematol Hemoter 2017;39:175-6 DOI: 10.1016/j.bjhh.2017.03.003
Images in Clinical Hematology
Oral lesions associated with Fanconi anemia
Eric T. Stoopler, , Lujain Homeida, Thomas P. Sollecito
University of Pennsylvania, School of Dental Medicine, Philadelphia, United States
Recebido 03 Março 2017, Aceitaram 24 Março 2017

A middle-aged man complained of symptomatic oral lesions. Family history was positive for Fanconi anemia (FA). An intraoral examination revealed generalized erythroleukoplakia with focal ulcerations affecting the palate (Figure 1). Differential diagnosis included lichenoid lesions, dysplasia and squamous cell carcinoma (SCC). Previous biopsies demonstrated mild to moderate dysplasia. The patient underwent genetic testing and was diagnosed with FA.

Figure 1.

Generalized erythroleukoplakia with focal ulcerations affecting the hard and soft palate.

FA is an autosomal recessive disorder characterized by physical abnormalities, bone marrow failure and predisposition to hematologic and solid malignancies.1 Oral findings associated with FA include mucosal lesions, periodontal disease and dental anomalies.2 FA patients are considered high-risk for oral SCC.3

Conflicts of interest

The authors declare no conflicts of interest.

References
1
A. Schifferli,T. Kuhne
Fanconi anemia overview of the disease and the role of hematopoietic transplantation
J Pediatr Hematol Oncol, 37 (2015), pp. 335-343 http://dx.doi.org/10.1097/MPH.0000000000000374
2
M. Goswami,U. Bhushan
Dental perspective of rare disease of Fanconi anemia: case report with review Clin Med Insights
Case Rep, 17 (2016), pp. 25-30
3
E. Velleuer,R. Dietrich
Fanconi anemia young patients at high risk for squamous cell carcinoma
Mol Cell Pediatr, 1 (2014), pp. 9 http://dx.doi.org/10.1186/s40348-014-0009-8
Corresponding author at: Department of Oral Medicine, University of Pennsylvania School of Dental Medicine, 240 South 40th Street, Philadelphia, PA 19104, USA.
Copyright © 2017. Associação Brasileira de Hematologia, Hemoterapia e Terapia Celular
Rev Bras Hematol Hemoter 2017;39:175-6 DOI: 10.1016/j.bjhh.2017.03.003