Revista Brasileira de Hematologia e Hemoterapia Revista Brasileira de Hematologia e Hemoterapia
Hematology,Transfusion and Cell Therapy 2018;40:18-24 DOI: 10.1016/j.bjhh.2017.09.002
Original article
Validation of the Brazilian version of the VERITAS-Pro scale to assess adherence to prophylactic regimens in hemophilia
Adriana Aparecida Ferreiraa,b,, , Isabel Cristina Gonçalves Leitea, Natalie August Duncanc
a Universidade Federal de Juiz de Fora UFJF, Juiz de Fora, MG, Brazil
b Fundação Centro de Hematologia e Hemoterapia de Minas Gerais Hemominas, Juiz de Fora, MG, Brazil
c Indiana Hemophilia and Thrombosis Center, Indianapolis, IN, USA
Recebido 04 Junho 2017, Aceitaram 15 Setembro 2017
Abstract
Introduction

Prophylaxis is the treatment of choice for patients with severe hemophilia. Low adherence may limit the effectiveness of the prophylactic regimen, thereby compromising outcomes.

Objective

The objective of this study was to validate the Brazilian version of the VERITAS-Pro prophylaxis adherence scale, originally an American questionnaire that can be answered by the individual responsible for prophylaxis as well as by an observer.

Methods

The scale has 24 questions divided into six subscales: Routine, Dosage, Plan, Remember, Skip and Communicate. Participants were recruited at a blood center in southeastern Brazil for validation and reliability analyses. Validation measures included the results obtained using analog visual scales of adherence, interval between medication dispensed by the treatment center pharmacy and the percentage of recommended doses administered and infusions registered in the patients’ logs.

Results

The study included 32 individuals responsible for prophylaxis and five observers. The internal consistency was very good for the VERITAS-Pro total score, excellent for the Remember, Skip and Communicate subscales, good for the Dosage subscale, and acceptable for the Routine and Plan subscales. Twelve participants answered the questionnaire on more than one occasion to evaluate reproducibility. The intraclass correlation coefficient was excellent. Regarding convergent validity, the VERITAS-Pro scores were moderately correlated with the global adherence scale and with infusion log records, but showed a weak correlation with pharmacy dispensation records.

Conclusion

The Brazilian version of VERITAS-Pro is a valid and reliable instrument, enabling the understanding of specific factors related to non-adherence and allowing targeted interventions for proper treatment.

Keywords
Hemophilia, Medication adherence, Questionnaire, Validation study
Hematology,Transfusion and Cell Therapy 2018;40:18-24 DOI: 10.1016/j.bjhh.2017.09.002