Met (Phospho Tyr1235) rabbit pAb

• Background :

  Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:Activation of MET after rearrangement with the TPR gene produces an oncogenic protein., disease:Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM:114550]., disease:Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM:605074]; also known as papillary renal cell carcinoma 2 (RCCP2) . HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance., disease:Defects in MET may be associated with gastric cancer., disease:Genetic variations in MET may be associated with susceptibility to autism type 9 (AUTS9) [MIM:611015]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior., domain:The kinase domain is involved in SPSB1 binding., function:Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival., online information:C-MET entry, similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Contains 1 protein kinase domain., similarity:Contains 1 Sema domain., similarity:Contains 3 IPT/TIG domains., subunit:Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity) . Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation.

• Description :

  Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Disease: Activation of MET after rearrangement with the TPR gene produces an oncogenic protein. Disease: Defects in MET are a cause of hepatocellular carcinoma (HCC) [MIM: 114550]. Disease: Defects in MET are a cause of hereditary papillary renal carcinoma (HPRC) [MIM: 605074]; also known as papillary renal cell carcinoma 2 (RCCP2). HPRC is a form of inherited kidney cancer characterized by a predisposition to develop multiple, bilateral papillary renal tumors. The pattern of inheritance is consistent with autosomal dominant transmission with reduced penetrance. Disease: Defects in MET may be associated with gastric cancer. Disease: Genetic variations in MET may be associated with susceptibility to autism type 9 (AUTS9) [MIM: 611015]. Autism is a neurodevelopmental disorder characterized by disturbance in language, perception and socialization. The disorder is classically defined by a triad of limited or absent verbal communication, a lack of reciprocal social interaction or responsiveness, and restricted, stereotypical, and ritualized patterns of interests and behavior. Domain: The kinase domain is involved in SPSB1 binding. function: Receptor for hepatocyte growth factor and scatter factor. Has a tyrosine-protein kinase activity. Functions in cell proliferation, scattering, morphogenesis and survival. online information: C-MET entry, similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. similarity: Contains 1 protein kinase domain. similarity: Contains 1 Sema domain. similarity: Contains 3 IPT/TIG domains. subunit: Heterodimer formed of an alpha chain (50 kDa) and a beta chain (145 kDa) which are disulfide linked. Binds PLXNB1 and GRB2. Interacts with SPSB1, SPSB2 and SPSB4 (By similarity). Interacts with INPP5D/SHIP1. When phosphorylated at Tyr-1356, interacts with INPPL1/SHIP2. Interacts with RANBP9 and RANBP10, as well as SPSB1, SPSB2, SPSB3 and SPSB4. SPSB1 binding occurs in the presence and in the absence of HGF, however HGF treatment has a positive effect on this interaction. Interacts with MUC20; prevents interaction with GRB2 and suppresses hepatocyte growth factor-induced cell proliferation.

• UniProt :

  P08581

• Swiss Prot :

  P08581

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human Met (Phospho Tyr1235)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Molecular Weight :

  140170kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  140170kD

• Fragment :

  IgG

• Subcellular Location :

  Membrane; Single-pass type I membrane protein.; [Isoform 3]: Secreted.

• Other Product Names :

  Hepatocyte growth factor receptor (HGF receptor; EC 2.7.10.1; HGF/SF receptor; Proto-oncogene c-Met; Scatter factor receptor; SF receptor; Tyrosine-protein kinase Met)

• Gene ID (Human) :

  4233