NDUFA1 Rabbit pAb

• Background :

  The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH:ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008]

• Description :

  The human NDUFA1 gene codes for an essential component of complex I of the respiratory chain, which transfers electrons from NADH to ubiquinone. It has been noted that the N-terminal hydrophobic domain has the potential to be folded into an alpha-helix spanning the inner mitochondrial membrane with a C-terminal hydrophilic domain interacting with globular subunits of complex I. The highly conserved two-domain structure suggests that this feature is critical for the protein function and might act as an anchor for the NADH: ubiquinone oxidoreductase complex at the inner mitochondrial membrane. However, the NDUFA1 peptide is one of about 31 components of the "hydrophobic protein" (HP) fraction of complex I which is involved in proton translocation. Thus the NDUFA1 peptide may also participate in that function. [provided by RefSeq, Jul 2008],

• Product Name Alternative :

  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE; CI-MWFE; NADH-ubiquinone oxidoreductase MWFE subunit)

• UniProt :

  O15239

• Swiss Prot :

  O15239

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human NDUFA1 AA range: 20-100

• Target :

  NDUFA1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  IHC-p 1:50-200, ELISA (peptide) 1:5000-20000

• Buffer :

  -20°C/1 year

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  Mitochondrion inner membrane ; Single-pass membrane protein ; Matrix side .

• Other Product Names :

  NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 1 (Complex I-MWFE; CI-MWFE; NADH-ubiquinone oxidoreductase MWFE subunit)

• Gene ID (Human) :

  4694