C/EBP β (Acetyl Lys265) rabbit pAb

• Background :

  Function:Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'., PTM:Sumoylated by polymeric chains of SUMO2 or SUMO3., similarity:Belongs to the bZIP family., similarity:Belongs to the bZIP family. C/EBP subfamily., similarity:Contains 1 bZIP domain., subunit:Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2., tissue specificity:Expressed at low levels in the lung, kidney and spleen.

• Description :

  Function: Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses. Specifically binds to an IL-1 response element in the IL-6 gene. NF-IL6 also binds to regulatory regions of several acute-phase and cytokines genes. It probably plays a role in the regulation of acute-phase reaction, inflammation and hemopoiesis. The consensus recognition site is 5'-T[TG]NNGNAA[TG]-3'. PTM: Sumoylated by polymeric chains of SUMO2 or SUMO3. similarity: Belongs to the bZIP family. similarity: Belongs to the bZIP family. C/EBP subfamily. similarity: Contains 1 bZIP domain. subunit: Binds DNA as a dimer and can form stable heterodimers with C/EBP alpha, delta and gamma. Interacts with TRIM28 and PTGES2. tissue specificity: Expressed at low levels in the lung, kidney and spleen.

• UniProt :

  P17676

• Swiss Prot :

  P17676

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human C/EBP β (Acetyl Lys265)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  40kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  40kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cytoplasm . Translocates to the nucleus when phosphorylated at Ser-288. In T-cells when sumoylated drawn to pericentric heterochromatin thereby allowing proliferation (By similarity) . .

• Other Product Names :

  CCAAT/enhancer-binding protein beta (C/EBP beta; Liver activator protein; Nuclear factor NF-IL6; Transcription factor 5; TCF-5)

• Gene ID (Human) :

  1051