TOP2A (Phospho Ser1213) rabbit pAb

• Background :

  Catalytic activity:ATP-dependent breakage, passage and rejoining of double-stranded DNA., enzyme regulation:Specifically inhibited by the intercalating agent amsacrine., function:Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks., miscellaneous:Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils., PTM:Phosphorylation has no effect on catalytic activity., similarity:Belongs to the type II topoisomerase family., subcellular location:Generally located in the nucleoplasm., subunit:Homodimer. Interacts with COPS5.

• Description :

  Catalytic activity: ATP-dependent breakage, passage and rejoining of double-stranded DNA. enzyme regulation: Specifically inhibited by the intercalating agent amsacrine. function: Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks. miscellaneous: Eukaryotic topoisomerase I and II can relax both negative and positive supercoils, whereas prokaryotic enzymes relax only negative supercoils. PTM: Phosphorylation has no effect on catalytic activity. similarity: Belongs to the type II topoisomerase family. subcellular location: Generally located in the nucleoplasm. subunit: Homodimer. Interacts with COPS5.

• UniProt :

  P11388

• Swiss Prot :

  P11388

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human TOP2A (Phospho Ser1213)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  174kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  174kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus, nucleoplasm . Nucleus . Nucleus, nucleolus .

• Other Product Names :

  DNA topoisomerase 2-alpha (EC 5.99.1.3; DNA topoisomerase II, alpha isozyme)

• Gene ID (Human) :

  7153