Endothelin B Receptor rabbit pAb

• Background :

  The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016]

• Description :

  The protein encoded by this gene is a G protein-coupled receptor which activates a phosphatidylinositol-calcium second messenger system. Its ligand, endothelin, consists of a family of three potent vasoactive peptides: ET1, ET2, and ET3. Studies suggest that the multigenic disorder, Hirschsprung disease type 2, is due to mutations in the endothelin receptor type B gene. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016],

• UniProt :

  P24530

• Swiss Prot :

  P24530

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthetic Peptide of Endothelin B Receptor AA range: 270-350

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; IF

• Concentration :

  1 mg/ml

• Dilution :

  IHC 1:100-200

• Molecular Weight :

  50kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  50kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Multi-pass membrane protein. internalized after activation by endothelins. .

• Other Product Names :

  Endothelin B receptor (ET-B; ET-BR; Endothelin receptor non-selective type)

• Gene ID (Human) :

  1910