CABP rabbit pAb

• Background :

  Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1,4,5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012]

• Description :

  Calcium binding proteins are an important component of calcium mediated cellular signal transduction. This gene encodes a protein that belongs to a subfamily of calcium binding proteins which share similarity to calmodulin. The protein encoded by this gene regulates the gating of voltage-gated calcium ion channels. This protein inhibits calcium-dependent inactivation and supports calcium-dependent facilitation of ion channels containing voltage-dependent L-type calcium channel subunit alpha-1C. This protein also regulates calcium-dependent activity of inositol 1, 4, 5-triphosphate receptors, P/Q-type voltage-gated calcium channels, and transient receptor potential channel TRPC5. This gene is predominantly expressed in retina and brain. Alternative splicing results in multiple transcript variants encoding disinct isoforms. [provided by RefSeq, Jul 2012],

• UniProt :

  Q9NZU7

• Swiss Prot :

  Q9NZU7

• Reactivity :

  Rat; Mouse

• Immunogen :

  Synthetic Peptide of CABP

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight :

  40kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  40kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cytoskeleton . Cytoplasm, perinuclear region . Cell membrane ; Lipid-anchor; Cytoplasmic side. Golgi apparatus . Cell junction, synapse, postsynaptic density . L-CaBP1 is associated most likely with the cytoskeletal structures, whereas S-CaBP1 is localized at or near the plasma membrane. .; [Isoform L-CaBP1]: Cytoplasm, cytoskeleton . L-CaBP1 is associated most likely with the cytoskeletal structures. .; [Isoform S-CaBP1]: Cytoplasm, cell cortex. Cell membrane ; Lipid-anchor . S-CaBP1 is localized at or near the plasma membrane.

• Other Product Names :

  Calcium-binding protein 1 (CaBP1; Calbrain; Caldendrin)

• Gene ID (Human) :

  9478