Crk-L rabbit pAb

• Background :

  This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic.[provided by RefSeq, Jan 2009]

• Description :

  This gene encodes a protein kinase containing SH2 and SH3 (src homology) domains which has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase, plays a role in fibroblast transformation by BCR-ABL, and may be oncogenic. [provided by RefSeq, Jan 2009],

• Product Name Alternative :

  CRKL; Crk-like protein

• UniProt :

  P46109

• Swiss Prot :

  P46109

• Reactivity :

  Human; Mouse; Rat; Monkey

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human CrkL. AA range:173-222

• Target :

  Crk-L

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  39kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  39kD

• Fragment :

  IgG

• Subcellular Location :

  Endosome, cytosol, cell-cell adherens junction, extracellular exosome

• Other Product Names :

  CRKL; Crk-like protein

• Gene ID (Human) :

  1399