DNA Ligase III rabbit pAb

• Background :

  This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

• Description :

  This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008],

• Product Name Alternative :

  LIG3; DNA ligase 3; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3

• UniProt :

  P49916

• Swiss Prot :

  P49916

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from DNA Ligase III . at AA range: 110-190

• Target :

  DNA Ligase III

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  100kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  100kD

• Fragment :

  IgG

• Subcellular Location :

  [Isoform 1]: Mitochondrion . Contains an N-terminal mitochondrial transit peptide. .; [Isoform 2]: Mitochondrion . Contains an N-terminal mitochondrial transit peptide. .; [Isoform 3]: Nucleus . Lacks the N-terminal mitochondrial transit peptide. .; [Isoform 4]: Nucleus . Lacks the N-terminal mitochondrial transit peptide. .

• Other Product Names :

  LIG3; DNA ligase 3; DNA ligase III; Polydeoxyribonucleotide synthase [ATP] 3

• Gene ID (Human) :

  3980