SOCS-1 rabbit pAb

• Background :

  This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN) -gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]

• Description :

  This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of Cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of Cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of Cytokine receptors, and takes part in a negative feedback loop to attenuate Cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008],

• UniProt :

  O15524

• Swiss Prot :

  O15524

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human SOCS-1. AA range:49-98

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IF; WB; IHC; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  IF: 1:50-200 WB 1:500-2000, ELISA 1:10000-20000 IHC 1:50-300

• Molecular Weight :

  38kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  38kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cytoplasmic vesicle . Detected in perinuclear cytoplasmic vesicles upon interaction with FGFR3.

• Other Product Names :

  SOCS1; SSI1; TIP3; Suppressor of cytokine signaling 1; SOCS-1; JAK-binding protein; JAB; STAT-induced STAT inhibitor 1; SSI-1; Tec-interacting protein 3; TIP-3

• Gene ID (Human) :

  8651