Tyk 2 rabbit pAb

• Background :

  Tyrosine kinase 2 (TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008]

• Description :

  Tyrosine kinase 2 (TYK2) Homo sapiens This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II Cytokine receptors and promulgate Cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E. [provided by RefSeq, Jul 2008],

• Product Name Alternative :

  TYK2; Non-receptor tyrosine-protein kinase TYK2

• UniProt :

  P29597

• Swiss Prot :

  P29597

• Reactivity :

  Human; Mouse; Monkey

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human TYK2. AA range:1020-1069

• Target :

  Tyk 2

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  134kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  134kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus, cytoplasm, cytosol, cytoskeleton, membrane, extrinsic component of cytoplasmic side of plasma membrane, extracellular exosome

• Other Product Names :

  TYK2; Non-receptor tyrosine-protein kinase TYK2

• Gene ID (Human) :

  7297