SV2C rabbit pAb

• Background :

  Function:Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles., PTM:N-glycosylated., similarity:Belongs to the major facilitator superfamily., subcellular location:Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas., subunit:Interacts with SYT1 in a calcium-dependent manner.

• Description :

  Function: Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles. PTM: N-glycosylated. similarity: Belongs to the major facilitator superfamily. subcellular location: Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. subunit: Interacts with SYT1 in a calcium-dependent manner.

• UniProt :

  Q496J9

• Swiss Prot :

  Q496J9

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from the Internal region of human SV2C.

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. IHC-p: 1:100-300 ELISA: 1/20000. Not yet tested in other applications.

• Molecular Weight :

  82kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  82kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane ; Multi-pass membrane protein . Enriched in small synaptic vesicles and adrenal microsomes, not present in chromaffin granules. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas. .

• Other Product Names :

  SV2C; KIAA1054; Synaptic vesicle glycoprotein 2C

• Gene ID (Human) :

  22987