ZnT-8 rabbit pAb

• Background :

  The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM) . Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2010]

• Description :

  The protein encoded by this gene is a zinc efflux transporter involved in the accumulation of zinc in intracellular vesicles. This gene is expressed at a high level only in the pancreas, particularly in islets of Langerhans. The encoded protein colocalizes with insulin in the secretory pathway granules of the insulin-secreting INS-1 cells. Allelic variants of this gene exist that confer susceptibility to diabetes mellitus, noninsulin-dependent (NIDDM). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2010],

• Product Name Alternative :

  SLC30A8; ZNT8; Zinc transporter 8; ZnT-8; Solute carrier family 30 member 8

• UniProt :

  Q8IWU4

• Swiss Prot :

  Q8IWU4

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human SLC30A8. AA range:171-220

• Target :

  ZnT-8

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  41kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  41kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Multi-pass membrane protein . Cytoplasmic vesicle, secretory vesicle membrane ; Multi-pass membrane protein . Associated with insulin and glucagon secretory granules. .

• Other Product Names :

  SLC30A8; ZNT8; Zinc transporter 8; ZnT-8; Solute carrier family 30 member 8

• Gene ID (Human) :

  169026