Melan-A rabbit pAb

• Background :

  Tissue specificity:Expression is restricted to melanoma and melanocyte cell lines and retina.

• Description :

  Tissue specificity: Expression is restricted to melanoma and melanocyte cell lines and retina.

• UniProt :

  Q16655

• Swiss Prot :

  Q16655

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human MART-1. AA range:41-90

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight :

  15kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  15kD

• Fragment :

  IgG

• Subcellular Location :

  Endoplasmic reticulum membrane; Single-pass type III membrane protein. Golgi apparatus. Golgi apparatus, trans-Golgi network membrane. Melanosome. Also found in small vesicles and tubules dispersed over the entire cytoplasm. A small fraction of the protein is inserted into the membrane in an inverted orientation. Inversion of membrane topology results in the relocalization of the protein from a predominant Golgi/post-Golgi area to the endoplasmic reticulum. Melanoma cells expressing the protein with an inverted membrane topology are more effectively recognized by specific cytolytic T-lymphocytes than those expressing the protein in its native membrane orientation.

• Other Product Names :

  MLANA; MART1; Melanoma antigen recognized by T-cells 1; MART-1; Antigen LB39-AA; Antigen SK29-AA; Protein Melan-A

• Gene ID (Human) :

  2315