GlyRβ rabbit pAb

• Background :

  This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

• Description :

  This gene encodes the beta subunit of the glycine receptor, which is a pentamer composed of alpha and beta subunits. The receptor functions as a neurotransmitter-gated ion channel, which produces hyperpolarization via increased chloride conductance due to the binding of glycine to the receptor. Mutations in this gene cause startle disease, also known as hereditary hyperekplexia or congenital stiff-person syndrome, a disease characterized by muscular rigidity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009],

• Product Name Alternative :

  GLRB; Glycine receptor subunit beta; Glycine receptor 58 kDa subunit

• UniProt :

  P48167

• Swiss Prot :

  P48167

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human GLRB. AA range:211-260

• Target :

  GlyRβ

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/40000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  56kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  56kD

• Fragment :

  IgG

• Subcellular Location :

  Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell projection, dendrite . Cell membrane ; Multi-pass membrane protein . Cytoplasm . Retained in the cytoplasm upon heterologous expression by itself. Coexpression with GPHN promotes expression at the cell membrane (PubMed:12684523) . Coexpression with GLRA1, GLRA2 or GLRA3 promotes expression at the cell membrane. .

• Other Product Names :

  GLRB; Glycine receptor subunit beta; Glycine receptor 58 kDa subunit

• Gene ID (Human) :

  2743