PinX1 rabbit pAb

• Background :

  Domain:The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity., function:Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor., similarity:Belongs to the PINX1 family., similarity:Contains 1 G-patch domain., subcellular location:In nucleoli and at telomere speckles., subunit:Binds to MCRS1, TERT and TERF1., tissue specificity:Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

• Description :

  Domain: The TID (telomerase inhibiting domain) domain is sufficient to bind TERT and inhibit its activity. function: Inhibits telomerase activity. May inhibit cell proliferation and act as tumor suppressor. similarity: Belongs to the PINX1 family. similarity: Contains 1 G-patch domain. subcellular location: In nucleoli and at telomere speckles. subunit: Binds to MCRS1, TERT and TERF1. tissue specificity: Ubiquitous; expressed at low levels. Not detectable in a number of hepatocarcinoma cell lines.

• UniProt :

  Q96BK5

• Swiss Prot :

  Q96BK5

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human PINX1. AA range:121-170

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Immunohistochemistry: 1/100 - 1/300. ELISA: 1/20000. Not yet tested in other applications.

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Nucleus, nucleolus. Chromosome, telomere. Chromosome, centromere, kinetochore. Localizes in nucleoli, at telomere speckles and to the outer plate of kinetochores. Localization to the kinetochore is mediated by its central region and depends on NDC80 and CENPE.

• Other Product Names :

  PINX1; LPTL; LPTS; PIN2/TERF1-interacting telomerase inhibitor 1; Liver-related putative tumor suppressor; Pin2-interacting protein X1; Protein 67-11-3; TRF1-interacting protein 1

• Gene ID (Human) :

  54984