RGS7 rabbit pAb

• Background :

  Function:Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G (o) -alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations., PTM:Palmitoylated., PTM:Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity., similarity:Contains 1 DEP domain., similarity:Contains 1 G protein gamma domain., similarity:Contains 1 RGS domain., subunit:Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity) . Interacts with 14-3-3 protein Tau and SNAP25BP.

• Description :

  Function: Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G (o)-alpha is specifically enhanced by the RGS6/GNG5 dimer. May play a role in synaptic vesicle exocytosis. May play important role in the rapid regulation of neuronal excitability and the cellular responses to short-lived stimulations. PTM: Palmitoylated. PTM: Phosphorylation and subsequent interaction with 14-3-3 proteins inhibits GAP activity. similarity: Contains 1 DEP domain. similarity: Contains 1 G protein gamma domain. similarity: Contains 1 RGS domain. subunit: Heterodimer with GNG5. Interacts with RGS7BP, leading to regulate the subcellular location of the heterodimer formed with Gbeta5 (By similarity). Interacts with 14-3-3 protein Tau and SNAP25BP.

• Product Name Alternative :

  RGS7; Regulator of G-protein signaling 7; RGS7

• UniProt :

  P49802

• Swiss Prot :

  P49802

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human RGS7. AA range:155-204

• Target :

  RGS7

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  65kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  65kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cytosol . Cytoplasm . Cell membrane . Membrane ; Peripheral membrane protein ; Cytoplasmic side . Interaction with PKD1 promotes location at the cell membrane (PubMed:10339594) . Interaction with RGS7BP promotes location at the cell membrane (PubMed:15897264) . .

• Other Product Names :

  RGS7; Regulator of G-protein signaling 7; RGS7

• Gene ID (Human) :

  6000