RO60 rabbit pAb

• Background :

  Disease:Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign., function:RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation., PTM:Phosphorylated upon DNA damage, probably by ATM or ATR., similarity:Belongs to the Ro 60 kDa family., similarity:Contains 1 TROVE domain., subunit:Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.

• Description :

  Disease: Sera from patients with systemic lupus erythematosus (SLE) often contain antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign. function: RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. similarity: Belongs to the Ro 60 kDa family. similarity: Contains 1 TROVE domain. subunit: Found in a complex with PUF60 and Y5 RNA. Interacts with RIP11.

• Product Name Alternative :

  TROVE2; RO60; SSA2; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; Ro 60 kDa autoantigen; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; SS-A; TROVE domain family member 2

• UniProt :

  P10155

• Swiss Prot :

  P10155

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human TROVE2. AA range:311-360

• Target :

  RO60

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300

• Buffer :

  -20°C/1 year

• Molecular Weight :

  70kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  70kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Localized in cytoplasmic mRNP granules containing untranslated mRNAs. .

• Other Product Names :

  TROVE2; RO60; SSA2; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; Ro 60 kDa autoantigen; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; SS-A; TROVE domain family member 2

• Gene ID (Human) :

  6738