TGIF rabbit pAb

• Background :

  The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provide

• Description :

  The protein encoded by this gene is a member of the three-amino acid loop extension (TALE) superclass of atypical homeodomains. TALE homeobox proteins are highly conserved transcription regulators. This particular homeodomain binds to a previously characterized retinoid X receptor responsive element from the cellular retinol-binding protein II promoter. In addition to its role in inhibiting 9-cis-retinoic acid-dependent RXR alpha transcription activation of the retinoic acid responsive element, the protein is an active transcriptional co-repressor of SMAD2 and may participate in the transmission of nuclear signals during development and in the adult. Mutations in this gene are associated with holoprosencephaly type 4, which is a structural anomaly of the brain. Alternative splicing has been observed at this locus and multiple splice variants encoding distinct isoforms are described. [provide

• Product Name Alternative :

  TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1

• UniProt :

  Q15583

• Swiss Prot :

  Q15583

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from the C-terminal region of human TGIF.

• Target :

  TGIF

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. ELISA: 1/10000. Not yet tested in other applications.

• Buffer :

  -20°C/1 year

• Molecular Weight :

  43kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  43kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus.

• Other Product Names :

  TGIF1; TGIF; Homeobox protein TGIF1; 5'-TG-3'-interacting factor 1

• Gene ID (Human) :

  7050