ZnT-4 rabbit pAb

• Background :

  Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e.g., MIM 114852), alkaline phosphatases (e.g., MIM 171760), various dehydrogenases, and superoxide dismutases (e.g., MIM 147450) . SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]) .[supplied by OMIM, Mar 2008]

• Description :

  Zinc is the second most abundant trace metal in the human body. It is an essential element, serving both a structural role, as in the formation of zinc fingers in DNA-binding proteins, and a catalytic role in metalloenzymes, such as pancreatic carboxypeptidases (e. g. MIM 114852), alkaline phosphatases (e. g. MIM 171760), various dehydrogenases, and superoxide dismutases (e. g. MIM 147450). SLC30A4, or ZNT4, belongs to the ZNT family of zinc transporters. ZNTs are involved in transporting zinc out of the cytoplasm and have similar structures, consisting of 6 transmembrane domains and a histidine-rich cytoplasmic loop (Huang and Gitschier, 1997 [PubMed 9354792]). [supplied by OMIM, Mar 2008],

• UniProt :

  O14863

• Swiss Prot :

  O14863

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  The antiserum was produced against synthesized peptide derived from human SLC30A4. AA range:71-120

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/5000. Not yet tested in other applications.

• Molecular Weight :

  47kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  47kD

• Fragment :

  IgG

• Subcellular Location :

  Endosome membrane ; Multi-pass membrane protein . Late endosome membrane ; Multi-pass membrane protein . Lysosome membrane ; Multi-pass membrane protein .

• Other Product Names :

  SLC30A4; ZNT4; Zinc transporter 4; ZnT-4; Solute carrier family 30 member 4

• Gene ID (Human) :

  7782