MIB1 rabbit pAb

• Background :

  This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1) . [provided by RefSeq, Jun 2013]

• Description :

  This gene encodes a protein containing multiple ankyrin repeats and RING finger domains that functions as an E3 ubiquitin ligase. The encoded protein positively regulates Notch signaling by ubiquitinating the Notch receptors, thereby facilitating their endocytosis. This protein may also promote the ubiquitination and degradation of death-associated protein kinase 1 (DAPK1). [provided by RefSeq, Jun 2013],

• Product Name Alternative :

  MIB1 DIP1 KIAA1323 ZZANK2

• UniProt :

  Q86YT6

• Swiss Prot :

  Q86YT6

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthetic peptide from human protein at AA range: 901-950

• Target :

  MIB1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  IHC-p: 100-300.WB 1:500-2000, ELISA 1:10000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  130kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  130kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite . Cell membrane . Localizes to the plasma membrane (By similarity) . According to PubMed:15048887, it is mitochondrial, however such localization remains unclear. Displaced from centriolar satellites in response to cellular stress, such as ultraviolet light (UV) radiation or heat shock. .

• Other Product Names :

  MIB1 DIP1 KIAA1323 ZZANK2

• Gene ID (Human) :

  57534