TOPRS rabbit pAb

• Background :

  This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010]

• Description :

  This gene encodes a nuclear protein which is serine and arginine rich, and contains a RING-type zinc finger domain. It is highly expressed in the testis, and functions as an ubiquitin-protein E3 ligase. Mutations in this gene are associated with retinitis pigmentosa type 31. Alternatively spliced transcript variants, encoding different isoforms, have been observed for this locus. [provided by RefSeq, Sep 2010],

• UniProt :

  Q9NS56

• Swiss Prot :

  Q9NS56

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Target :

  TOPRS

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  114kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  114kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus. Nucleus, PML body. Localizes to discrete nuclear foci which partly overlap with PML nuclear bodies. Targeted to PML nuclear bodies upon DNA damage.

• Gene ID (Human) :

  10210