JAML1 rabbit pAb

• Background :

  Domain:The Ig-like V-type domain 2 mediates interaction with CXADR., function:May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells., induction:Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells., similarity:Belongs to the immunoglobulin superfamily., similarity:Contains 2 Ig-like V-type (immunoglobulin-like) domains., subcellular location:Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN., subunit:Interacts with CXADR., tissue specificity:Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus.

• Description :

  Domain: The Ig-like V-type domain 2 mediates interaction with CXADR. function: May function in transmigration of leukocytes through epithelial and endothelial tissues. Expressed at the plasma membrane of polymorphonuclear leukocytes, it mediates adhesive interactions with CXADR, a protein of the junctional complex of epithelial cells. Enhances myeloid leukemia cell adhesion to endothelial cells. induction: Up-regulated upon retinoic acid, Me2SO and PMA treatment in differentiating myeloid leukemia cells. similarity: Belongs to the immunoglobulin superfamily. similarity: Contains 2 Ig-like V-type (immunoglobulin-like) domains. subcellular location: Localized at the plasma membrane in areas of cell-cell contacts and at the cell surface of PMN. subunit: Interacts with CXADR. tissue specificity: Expression is restricted to the hematopoietic tissues with the exception of liver. Expressed in fetal liver, spleen and thymus.

• UniProt :

  Q86YT9

• Swiss Prot :

  Q86YT9

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Target :

  JAML1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  43kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  43kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Single-pass type I membrane protein . Cell junction . Localized at the plasma membrane and enriched in areas of cell-cell contacts (PubMed:12869515) .

• Gene ID (Human) :

  120425