NRBP rabbit pAb

• Background :

  Caution:Author states that kinase activity observed in PubMed:11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive., domain:The protein kinase domain is predicted to be catalytically inactive., function:May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication., similarity:Belongs to the protein kinase superfamily. Ser/Thr protein kinase family., similarity:Contains 1 protein kinase domain., subcellular location:Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia., subunit:Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm., tissue specificity:Ubiquitously expressed in all tissues examined with high levels in the testis.

• Description :

  Caution: Author states that kinase activity observed in PubMed: 11956649 may be due to sample contamination. This protein is predicted to be catalytically inactive. Domain: The protein kinase domain is predicted to be catalytically inactive. function: May play a role in subcellular trafficking between the endoplasmic reticulum and Golgi apparatus through interactions with the Rho-type GTPases. Binding to the NS3 protein of dengue virus type 2 appears to subvert this activity into the alteration of the intracellular membrane structure associated with flaviviral replication. similarity: Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. similarity: Contains 1 protein kinase domain. subcellular location: Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia. subunit: Homodimer. Binds to MLF1, recruiting a serine kinase which phosphorylates both itself and MLF1. Phosphorylated MLF1 binds to YWHAZ and is retained in the cytoplasm. tissue specificity: Ubiquitously expressed in all tissues examined with high levels in the testis.

• UniProt :

  Q9UHY1

• Swiss Prot :

  Q9UHY1

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Target :

  NRBP

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  58kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  58kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cell cortex . Endomembrane system . Cell projection, lamellipodium . Colocalizes with activated RAC3 to endomembranes and at the cell periphery in lamellipodia.

• Gene ID (Human) :

  29959