TNKS1 rabbit pAb

• Background :

  Catalytic activity:NAD (+) + (ADP-D-ribosyl) (n) -acceptor = nicotinamide + (ADP-D-ribosyl) (n+1) -acceptor., function:May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length., PTM:ADP-ribosylated (-auto) ., PTM:Phosphorylated on serine residues by MAPK kinases upon insulin stimulation., similarity:Contains 1 PARP catalytic domain., similarity:Contains 1 SAM (sterile alpha motif) domain., similarity:Contains 15 ANK repeats., subcellular location:Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1., subunit:Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2., tissue specificity:Ubiquitous; highest levels in testis.

• Description :

  Catalytic activity: NAD (+) + (ADP-D-ribosyl) (n)-acceptor = nicotinamide + (ADP-D-ribosyl) (n+1)-acceptor. function: May regulate vesicle trafficking and modulate the subcellular distribution of SLC2A4/GLUT4-vesicles. Has PARP activity and can modify TERF1, and thereby contribute to the regulation of telomere length. PTM: ADP-ribosylated (-auto). PTM: Phosphorylated on serine residues by MAPK kinases upon insulin stimulation. similarity: Contains 1 PARP catalytic domain. similarity: Contains 1 SAM (sterile alpha motif) domain. similarity: Contains 15 ANK repeats. subcellular location: Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles. A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres. During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1. subunit: Oligomerizes and associates with TNKS2. Interacts with the cytoplasmic domain of LNPEP/Otase in SLC2A4/GLUT4-vesicles. Binds to the N-terminus of telomeric TERF1 via the ANK repeats. Found in a complex with POT1; TERF1 and TINF2. tissue specificity: Ubiquitous; highest levels in testis.

• UniProt :

  O95271

• Swiss Prot :

  O95271

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from part region of human protein

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000 ELISA 1:5000-20000

• Molecular Weight :

  145kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  145kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Golgi apparatus membrane ; Peripheral membrane protein . Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus, nuclear pore complex . Chromosome, telomere . Cytoplasm, cytoskeleton, spindle pole . Associated with the Golgi and with juxtanuclear SLC2A4/GLUT4-vesicles (PubMed:22864114) . A minor proportion is also found at nuclear pore complexes and around the pericentriolar matrix of mitotic centromeres (PubMed:10523501) . During interphase, a small fraction of TNKS is found in the nucleus, associated with TERF1 (PubMed:12768206) . Localizes to spindle poles at mitosis onset via interaction with NUMA1 (PubMed:12080061) . .

• Gene ID (Human) :

  8658