CGAS rabbit pAb

• UniProt :

  Q8N884

• Swiss Prot :

  Q8N884

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human M21D1 AA range: 35-85

• Target :

  M21D1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000

• Buffer :

  -20°C/1 year

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Chromosome . Cell membrane ; Peripheral membrane protein . Cytoplasm, cytosol . Mainly localizes in the nucleus, and at low level in the cytosol (PubMed:31808743, PubMed:31544964) . On chromosomes, enriched on centromeric satellite and LINE DNA repeat elements (PubMed:30811988) . Exported from the nucleus to the cytosol in a XPO1/CRM1 via the nuclear export signal in response to DNA stimulation (PubMed:33406424) . Outside the nucleus, localizes at the cell membrane as a peripheral membrane protein in resting conditions: association to the cell membrane is mediated via binding to phosphatidylinositol 4,5-bisphosphate (PtdIns (4,5) P2) (PubMed:30827685) . Localization at the cell membrane is required to limit the recognition of self-DNA (PubMed:30827685) . Following detection of double-st

• Gene ID (Human) :

  115004