SC6A4 rabbit pAb

• Background :

  This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008]

• Description :

  This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium: neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake and may play a role in sudden infant death syndrome, aggressive behavior in Alzheimer disease patients, and depression-susceptibility in people experiencing emotional trauma. [provided by RefSeq, Jul 2008],

• UniProt :

  P31645

• Swiss Prot :

  P31645

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human SC6A4

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. Immunofluorescence: 1/200 - 1/1000. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight :

  69kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  69kD

• Fragment :

  IgG

• Subcellular Location :

  Cell membrane ; Multi-pass membrane protein . Endomembrane system ; Multi-pass membrane protein . Endosome membrane ; Multi-pass membrane protein . Cell junction, synapse . Cell junction, focal adhesion . Could be part of recycling endosomes (PubMed:16870614) . Density of transporter molecules on the plasma membrane is itself regulated by STX1A (By similarity) . Density of transporter molecules on the plasma membrane is also regulated by serotonin (PubMed:17506858) . Density of transporter molecules seems to be modulated by ITGAV:ITGB3 (By similarity) . .

• Other Product Names :

  Sodium-dependent serotonin transporter (5HT transporter;5HTT; Solute carrier family 6 member 4)

• Gene ID (Human) :

  6532