Sp1 (Acetyl Lys703) rabbit pAb

• Background :

  Function:Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter., PTM:O-glycosylated; contains N-acetylglucosamine side chains., similarity:Belongs to the Sp1 C2H2-type zinc-finger protein family., similarity:Contains 3 C2H2-type zinc fingers., subunit:Interacts with ATF7IP, ATF7IP2, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein and HIV-1 Vpr. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the two proteins in DNA binding.

• Description :

  Function: Binds to GC box promoters elements and selectively activates mRNA synthesis from genes that contain functional recognition sites. Can interact with G/C-rich motifs from serotonin receptor promoter. PTM: O-glycosylated; contains N-acetylglucosamine side chains. similarity: Belongs to the Sp1 C2H2-type zinc-finger protein family. similarity: Contains 3 C2H2-type zinc fingers. subunit: Interacts with ATF7IP, ATF7IP2, POGZ, HCFC1, AATF and PHC2. Interacts with varicella-zoster virus IE62 protein and HIV-1 Vpr. Interacts with SV40 VP2/3 proteins. Interacts with SV40 major capsid protein VP1; this interaction leads to a cooperativity between the two proteins in DNA binding.

• UniProt :

  P08047

• Swiss Prot :

  P08047

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human Sp1 (Acetyl Lys703)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300

• Molecular Weight :

  90kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  90kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus. Cytoplasm. Nuclear location is governed by glycosylated/phosphorylated states. Insulin promotes nuclear location, while glucagon favors cytoplasmic location.

• Other Product Names :

  Transcription factor Sp1

• Gene ID (Human) :

  6667