FAK (Phospho Ser722) rabbit pAb

• Background :

  Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., domain:The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions., domain:The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL., function:Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity., PTM:Phosphorylated on 6 tyrosine residues upon activation., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily., similarity:Contains 1 FERM domain., similarity:Contains 1 protein kinase domain., subcellular location:Constituent of focal adhesions., subunit:Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with RGNEF and SHB (By similarity) . Interacts with TGFB1I1., tissue specificity:Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.

• Description :

  Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Domain: The carboxy-terminal region is the site of focal adhesion targeting (FAT) sequence which mediates the localization of FAK1 to focal adhesions. Domain: The first Pro-rich domain interacts with the SH3 domain of CRK-associated substrate (BCAR1) and CASL. function: Non-receptor protein-tyrosine kinase implicated in signaling pathways involved in cell motility, proliferation and apoptosis. Activated by tyrosine-phosphorylation in response to either integrin clustering induced by cell adhesion or antibody cross-linking, or via G-protein coupled receptor (GPCR) occupancy by ligands such as bombesin or lysophosphatidic acid, or via LDL receptor occupancy. Plays a potential role in oncogenic transformations resulting in increased kinase activity. PTM: Phosphorylated on 6 tyrosine residues upon activation. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. FAK subfamily. similarity: Contains 1 FERM domain. similarity: Contains 1 protein kinase domain. subcellular location: Constituent of focal adhesions. subunit: Interacts with CAS family members and with GIT1, SORBS1 and BCAR3. Interacts with RGNEF and SHB (By similarity). Interacts with TGFB1I1. tissue specificity: Expressed in all organs tested, in lymphoid cell lines, but most abundantly in brain.

• Product Name Alternative :

  Focal adhesion kinase 1 (FADK 1; EC 2.7.10.2; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK)

• UniProt :

  Q05397

• Swiss Prot :

  Q05397

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human FAK (Phospho Ser722)

• Target :

  FAK

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  125kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  125kD

• Fragment :

  IgG

• Subcellular Location :

  Cell junction, focal adhesion. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cell cortex. Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Nucleus. Cytoplasm, cytoskeleton, cilium basal body . Constituent of focal adhesions. Detected at microtubules.

• Other Product Names :

  Focal adhesion kinase 1 (FADK 1; EC 2.7.10.2; Focal adhesion kinase-related nonkinase; FRNK; Protein phosphatase 1 regulatory subunit 71; PPP1R71; Protein-tyrosine kinase 2; p125FAK; pp125FAK)

• Gene ID (Human) :

  5747