CAD (phospho-Ser1859) rabbit pAb

• Background :

  The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]

• Description :

  The de novo synthesis of pyrimidine nucleotides is required for mammalian cells to proliferate. This gene encodes a trifunctional protein which is associated with the enzymatic activities of the first 3 enzymes in the 6-step pathway of pyrimidine biosynthesis: carbamoylphosphate synthetase (CPS II), aspartate transcarbamoylase, and dihydroorotase. This protein is regulated by the mitogen-activated protein kinase (MAPK) cascade, which indicates a direct link between activation of the MAPK cascade and de novo biosynthesis of pyrimidine nucleotides. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015],

• UniProt :

  P27708

• Swiss Prot :

  P27708

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized phosho peptide around human CAD (Ser1859)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000

• Molecular Weight :

  250kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  250kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Nucleus . Cytosolic and unphosphorylated in resting cells, translocates to the nucleus in response to EGF stimulation, nuclear import promotes optimal cell growth.

• Other Product Names :

  CAD protein [Includes: Glutamine-dependent carbamoyl-phosphate synthase (EC 6.3.5.5) ; Aspartate carbamoyltransferase (EC 2.1.3.2) ; Dihydroorotase (EC 3.5.2.3) ]

• Gene ID (Human) :

  790