Cyclin D1 (Phospho Ser90) rabbit pAb

• Background :

  Disease:A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL) . Translocation t (11;14) (q13; q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle., disease:A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM:254500]. Translocation t (11;14) (q13; q32) with the IgH locus., disease:A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM:168461]. Translocation t (11;11) (q13; p15) with the parathyroid hormone (PTH) enhancer., function:Essential for the control of the cell cycle at the G1/S (start) transition., online information:The Singapore human mutation and polymorphism database, PTM:Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest., PTM:Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex., similarity:Belongs to the cyclin family., similarity:Belongs to the cyclin family. Cyclin D subfamily., subunit:Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

• Description :

  Disease: A chromosomal aberration involving CCND1 may be a cause of B-lymphocytic malignancy, particularly mantle-cell lymphoma (MCL). Translocation t (11;14) (q13;q32) with immunoglobulin gene regions. Activation of CCND1 may be oncogenic by directly altering progression through the cell cycle. Disease: A chromosomal aberration involving CCND1 may be a cause of multiple myeloma [MIM: 254500]. Translocation t (11;14) (q13;q32) with the IgH locus. Disease: A chromosomal aberration involving CCND1 may be a cause of parathyroid adenomas [MIM: 168461]. Translocation t (11;11) (q13;p15) with the parathyroid hormone (PTH) enhancer. function: Essential for the control of the cell cycle at the G1/S (start) transition. online information: The Singapore human mutation and polymorphism database, PTM: Following DNA damage it is ubiquitinated by some SCF (SKP1-cullin-F-box) protein ligase complex containing FBXO31. Ubiquitination leads to its degradation and G1 arrest. PTM: Phosphorylation at Thr-286 by MAP kinases is required for ubiquitination and degradation following DNA damage. It probably plays an essential role for recognition by the FBXO31 component of SCF (SKP1-cullin-F-box) protein ligase complex. similarity: Belongs to the cyclin family. similarity: Belongs to the cyclin family. Cyclin D subfamily. subunit: Interacts with the CDK4 and CDK6 protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex.

• Product Name Alternative :

  G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene)

• UniProt :

  P24385

• Swiss Prot :

  P24385

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human Cyclin D1 (Phospho Ser90)

• Target :

  Cyclin D1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  33kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  33kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cytoplasm . Nucleus membrane . Cyclin D-CDK4 complexes accumulate at the nuclear membrane and are then translocated to the nucleus through interaction with KIP/CIP family members. .

• Other Product Names :

  G1/S-specific cyclin-D1 (B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene)

• Gene ID (Human) :

  595