PUS10 rabbit pAb

• Background :

  Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]) .[supplied by OMIM, May 2009]

• Description :

  Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al. 2007 [PubMed 17900615]). [supplied by OMIM, May 2009],

• UniProt :

  Q3MIT2

• Swiss Prot :

  Q3MIT2

• Reactivity :

  Human; Mouse

• Immunogen :

  Synthesized peptide derived from human PUS10 AA range: 425-475

• Target :

  PUS10

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Buffer :

  -20°C/1 year

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Cytoplasm . Mitochondrion . Localizes mainly in the nucleus (Probable) (PubMed:31819270) . tRNA pseudouridylate synthase activity is restricted to the cytoplasm (PubMed:31819270) . Translocates from nucleus to mitochondria during TRAIL-induced apoptosis (PubMed:28981101) . .

• Gene ID (Human) :

  150962