Caspase 4 (p10, Cleaved-Ala290) rabbit pAb

• Background :

  Catalytic activity:Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-., function:Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1., PTM:The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8., similarity:Belongs to the peptidase C14A family., similarity:Contains 1 CARD domain., subunit:Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit., tissue specificity:Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.

• Description :

  Catalytic activity: Strict requirement for Asp at the P1 position. It has a preferred cleavage sequence of Tyr-Val-Ala-Asp-|- but also cleaves at Asp-Glu-Val-Asp-|-. function: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves caspase-1. PTM: The two subunits are derived from the precursor sequence by an autocatalytic mechanism or by cleavage by Caspase-8. similarity: Belongs to the peptidase C14A family. similarity: Contains 1 CARD domain. subunit: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a small and a large subunit. tissue specificity: Widely expressed, with highest levels in spleen and lung. Moderate expression in heart and liver, low expression in skeletal muscle, kidney and testis. Not found in the brain.

• UniProt :

  P49662

• Swiss Prot :

  P49662

• Reactivity :

  Human

• Immunogen :

  Synthesized peptide derived from human Caspase 4 (p10, Cleaved-Ala290)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  10 42kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  10 42kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cytosol . Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Mitochondrion . Inflammasome . Secreted . Predominantly localizes to the endoplasmic reticulum (ER) . Association with the ER membrane requires TMEM214 (PubMed:15123740) . Released in the extracellular milieu by keratinocytes following UVB irradiation (PubMed:22246630) . .

• Other Product Names :

  Caspase-4 (CASP-4; EC 3.4.22.57; ICE (rel) -II; Protease ICH-2; Protease TX) [Cleaved into: Caspase-4 subunit 1; Caspase-4 subunit 2]

• Gene ID (Human) :

  837