Desmoplakin (phospho-Ser165/166) rabbit pAb

• Background :

  This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

• Description :

  This gene encodes a protein that anchors intermediate filaments to desmosomal plaques and forms an obligate component of functional desmosomes. Mutations in this gene are the cause of several cardiomyopathies and keratodermas, including skin fragility-woolly hair syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016],

• UniProt :

  P15924

• Swiss Prot :

  P15924

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized phosho peptide around human Desmoplakin (Ser165 and 166)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000

• Molecular Weight :

  300kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  300kD

• Fragment :

  IgG

• Subcellular Location :

  Cell junction, desmosome . Cytoplasm, cytoskeleton . Cell membrane . Innermost portion of the desmosomal plaque. Colocalizes with epidermal KRT5-KRT14 and simple KRT8-KRT18 keratins and VIM intermediate filaments network (PubMed:12802069) . Localizes at the intercalated disk in cardiomyocytes (By similarity) . .

• Other Product Names :

  Desmoplakin (DP) (250/210 kDa paraneoplastic pemphigus antigen)

• Gene ID (Human) :

  1832