C-Myc (Acetyl Lys148) rabbit pAb

• Background :

  Disease:A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t (8;12) (q24; q22) with BTG1., disease:Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors., function:Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes., online information:Myc entry, PTM:Phosphorylated by PRKDC., similarity:Contains 1 basic helix-loop-helix (bHLH) domain., subunit:Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.

• Description :

  Disease: A chromosomal aberration involving MYC may be a cause of a form of B-cell chronic lymphocytic leukemia. Translocation t (8;12) (q24;q22) with BTG1. Disease: Overexpression of MYC is implicated in the etiology of a variety of hematopoietic tumors. function: Participates in the regulation of gene transcription. Binds DNA both in a non-specific manner and also specifically to recognizes the core sequence 5'-CAC[GA]TG-3'. Seems to activate the transcription of growth-related genes. online information: Myc entry, PTM: Phosphorylated by PRKDC. similarity: Contains 1 basic helix-loop-helix (bHLH) domain. subunit: Efficient DNA binding requires dimerization with another bHLH protein. Binds DNA as a heterodimer with MAX. Interacts with TAF1C and SPAG9. Interacts with PARP10. Interacts with KDM5A and KDM5B.

• UniProt :

  P01106

• Swiss Prot :

  P01106

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human c-Myc (Acetyl Lys148)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  55kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  55kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus, nucleoplasm . Nucleus, nucleolus .

• Other Product Names :

  Myc proto-oncogene protein (Class E basic helix-loop-helix protein 39; bHLHe39; Proto-oncogene c-Myc; Transcription factor p64)

• Gene ID (Human) :

  4609