Plasma Kallikrein LC (Cleaved-I391) rabbit pAb

• Background :

  Catalytic activity:Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin., disease:Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM:612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect., function:The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin., similarity:Belongs to the peptidase S1 family., similarity:Belongs to the peptidase S1 family. Plasma kallikrein subfamily., similarity:Contains 1 peptidase S1 domain., similarity:Contains 4 apple domains., subunit:The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.

• Description :

  Catalytic activity: Cleaves selectively Arg-|-Xaa and Lys-|-Xaa bonds, including Lys-|-Arg and Arg-|-Ser bonds in (human) kininogen to release bradykinin. Disease: Defects in KLKB1 are the cause of prekallikrein deficiency (PKK deficiency) [MIM: 612423]; also called Fletcher factor deficiency. This disorder is a blood coagulation defect. function: The enzyme cleaves Lys-Arg and Arg-Ser bonds. It activates, in a reciprocal reaction, factor XII after its binding to a negatively charged surface. It also releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. similarity: Belongs to the peptidase S1 family. similarity: Belongs to the peptidase S1 family. Plasma kallikrein subfamily. similarity: Contains 1 peptidase S1 domain. similarity: Contains 4 apple domains. subunit: The zymogen is activated by factor XIIa, which cleaves the molecule into a light chain, which contains the active site, and a heavy chain, which associates with HMW kininogen. These chains are linked by one or more disulfide bonds.

• UniProt :

  P03952

• Swiss Prot :

  P03952

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthesized peptide derived from human Plasma Kallikrein LC (Cleaved-I391)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Molecular Weight :

  28 70kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  28 70kD

• Fragment :

  IgG

• Subcellular Location :

  Secreted.

• Other Product Names :

  Plasma kallikrein (EC 3.4.21.34; Fletcher factor; Kininogenin; Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain]

• Gene ID (Human) :

  3818