Bcl-6 (Acetyl Lys379) rabbit pAb

• Background :

  Disease:A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27; q23) with POU2AF1/OBF1., disease:A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t (3;4) (q27; p11) with ARHH/TTF., disease:Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t (3;14) (q27; q32) ; translocation t (3;22) (q27; q11) with immunoglobulin gene regions., function:Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis., induction:Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan., PTM:Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway., similarity:Contains 1 BTB (POZ) domain., similarity:Contains 6 C2H2-type zinc fingers., subunit:Interacts with ZBTB7 and BCL6B (By similarity) . Interacts with the catalytic domain of HDAC9., tissue specificity:Expressed in germinal center T and B cells and in primary immature dendritic cells.

• Description :

  Disease: A chromosomal aberration involving BCL6 may be a cause of a form of B-cell leukemia. Translocation t (3;11) (q27;q23) with POU2AF1/OBF1. Disease: A chromosomal aberration involving BCL6 may be a cause of lymphoma. Translocation t (3;4) (q27;p11) with ARHH/TTF. Disease: Chromosomal aberrations involving BCL6 may be a cause of B-cell non-Hodgkin lymphoma. Translocation t (3;14) (q27;q32); translocation t (3;22) (q27;q11) with immunoglobulin gene regions. function: Transcriptional repressor which is required for germinal center formation and antibody affinity maturation. Probably plays an important role in lymphomagenesis. induction: Down-regulated during maturation of dendritic cells by selective stimuli such as LPS, CD40L and zymosan. PTM: Phosphorylated by MAPK1 in response to antigen receptor activation. Phosphorylation induces its degradation by ubiquitin/proteasome pathway. similarity: Contains 1 BTB (POZ) domain. similarity: Contains 6 C2H2-type zinc fingers. subunit: Interacts with ZBTB7 and BCL6B (By similarity). Interacts with the catalytic domain of HDAC9. tissue specificity: Expressed in germinal center T and B cells and in primary immature dendritic cells.

• UniProt :

  P41182

• Swiss Prot :

  P41182

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human Bcl-6 (Acetyl Lys379)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  80kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  80kD

• Fragment :

  IgG

• Subcellular Location :

  Nucleus .

• Other Product Names :

  B-cell lymphoma 6 protein (BCL-6; B-cell lymphoma 5 protein; BCL-5; Protein LAZ-3; Zinc finger and BTB domain-containing protein 27; Zinc finger protein 51)

• Gene ID (Human) :

  604