HMG-1 (Acetyl Lys82) rabbit pAb

• Background :

  Function:Binds preferentially single-stranded DNA and unwinds double stranded DNA., similarity:Belongs to the HMGB family., similarity:Contains 2 HMG box DNA-binding domains.

• Description :

  Function: Binds preferentially single-stranded DNA and unwinds double stranded DNA. similarity: Belongs to the HMGB family. similarity: Contains 2 HMG box DNA-binding domains.

• UniProt :

  P09429

• Swiss Prot :

  P09429

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human HMG-1 (Acetyl Lys82)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  about 30kd

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  About 30kd

• Fragment :

  IgG

• Subcellular Location :

  Nucleus . Chromosome . Cytoplasm . Secreted . Cell membrane ; Peripheral membrane protein ; Extracellular side . Endosome . Endoplasmic reticulum-Golgi intermediate compartment . In basal state predominantly nuclear. Shuttles between the cytoplasm and the nucleus (PubMed:12231511, PubMed:17114460) . Translocates from the nucleus to the cytoplasm upon autophagy stimulation (PubMed:20819940) . Release from macrophages in the extracellular milieu requires the activation of NLRC4 or NLRP3 inflammasomes (By similarity) . Passively released to the extracellular milieu from necrotic cells by diffusion, involving the fully reduced HGMB1 which subsequently gets oxidized (PubMed:19811284) . Also released from apoptotic cells (PubMed:16855214, PubMed:18631454) . Active secretion from a variety of immune a

• Other Product Names :

  High mobility group protein B1 (High mobility group protein 1; HMG-1)

• Gene ID (Human) :

  3146