NBR1 Rabbit rabbit pAb

• Background :

  The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21.1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014]

• Description :

  The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled-coil motif, which is present in many genes with transformation potential. It functions as a specific autophagy receptor for the selective autophagic degradation of peroxisomes by forming intracellular inclusions with ubiquitylated autophagic substrates. This gene is located on a region of chromosome 17q21. 1 that is in close proximity to the BRCA1 tumor suppressor gene. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Apr 2014],

• UniProt :

  Q14596

• Swiss Prot :

  Q14596

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Recombinant Protein of NBR1

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; IF

• Concentration :

  1 mg/ml

• Dilution :

  IHC-p 1:50-300

• Molecular Weight :

  120kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  120kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Cytoplasmic vesicle, autophagosome . Lysosome . Cytoplasm, myofibril, sarcomere, M line . In cardiac muscles localizes to the sarcomeric M line (By similarity) . Is targeted to lysosomes for degradation (PubMed:19250911) . .

• Other Product Names :

  Next to BRCA1 gene 1 protein (Cell migration-inducing gene 19 protein; Membrane component chromosome 17 surface marker 2; Neighbor of BRCA1 gene 1 protein; Protein 1A1-3B)

• Gene ID (Human) :

  4077