HER2 (Phospho Thr686) rabbit pAb

• Background :

  Catalytic activity:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate., disease:Defects in ERBB2 are associated with familial glioma of brain [MIM:137800]; also called glioblastoma multiforme. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas., disease:Defects in ERBB2 are associated with gastric cancer [MIM:137215]; also known as hereditary familial diffuse gastric cancer (HDGC) ., disease:Defects in ERBB2 are associated with lung cancer [MIM:211980]; also called adenocarcinoma of lung., disease:Defects in ERBB2 are associated with ovarian cancer [MIM:167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome., function:Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin., online information:ERBB2 entry, polymorphism:There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0.782; allele B2 (Ile-654/Val-655) has a frequency of 0.206; allele B3 (Val-654/Val-655) has a frequency of 0.012., PTM:Ligand-binding increases phosphorylation on tyrosine residues., similarity:Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily., similarity:Contains 1 protein kinase domain., subunit:Heterodimer with each of the other ERBB receptors (Potential) . Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell lines induces binding of MUC1 with gamma-catenin.

• Description :

  Catalytic activity: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. Disease: Defects in ERBB2 are associated with familial glioma of brain [MIM: 137800]; also called glioblastoma multiforme. Gliomas are central nervous system neoplasms derived from glial cells and comprise astrocytomas, glioblastoma multiforme, oligodendrogliomas, and ependymomas. Disease: Defects in ERBB2 are associated with gastric cancer [MIM: 137215]; also known as hereditary familial diffuse gastric cancer (HDGC). Disease: Defects in ERBB2 are associated with lung cancer [MIM: 211980]; also called adenocarcinoma of lung. Disease: Defects in ERBB2 are associated with ovarian cancer [MIM: 167000]. Ovarian cancer is the leading cause of death from gynecologic malignancy. It is characterized by advanced presentation with loco-regional dissemination in the peritoneal cavity and the rare incidence of visceral metastases. These typical features relate to the biology of the disease, which is a principal determinant of outcome. function: Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Not activated by EGF, TGF-alpha and amphiregulin. online information: ERBB2 entry, polymorphism: There are fours alleles due to the variations in positions 654 and 655. Allele B1 (Ile-654/Ile-655) has a frequency of 0. 782; allele B2 (Ile-654/Val-655) has a frequency of 0. 206; allele B3 (Val-654/Val-655) has a frequency of 0. 012. PTM: Ligand-binding increases phosphorylation on tyrosine residues. similarity: Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily. similarity: Contains 1 protein kinase domain. subunit: Heterodimer with each of the other ERBB receptors (Potential). Interacts with PRKCABP and PLXNB1. Part of a complex with EGFR and either PIK3C2A or PIK3C2B. May interact with PIK3C2B when phosphorylated on Tyr-1196. Interacts with MEMO when phosphorylated on Tyr-1248. Interacts with MUC1. Stimulation by heregulin (HRG) in breast cancer cell lines induces binding of MUC1 with gamma-catenin.

• UniProt :

  P04626

• Swiss Prot :

  P04626

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human HER2 (Phospho Thr686)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:1000-2000 ELISA 1:5000-20000

• Molecular Weight :

  180kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  180kD

• Fragment :

  IgG

• Subcellular Location :

  [Isoform 1]: Cell membrane ; Single-pass type I membrane protein. Early endosome . Cytoplasm, perinuclear region. Nucleus. Translocation to the nucleus requires endocytosis, probably endosomal sorting and is mediated by importin beta-1/KPNB1. Also detected in VPS35-positive endosome-to-TGN retrograde vesicles (PubMed:31138794) . .; [Isoform 2]: Cytoplasm. Nucleus.; [Isoform 3]: Cytoplasm. Nucleus.

• Other Product Names :

  Receptor tyrosine-protein kinase erbB-2 (EC 2.7.10.1; Metastatic lymph node gene 19 protein; MLN 19; Proto-oncogene Neu; Proto-oncogene c-ErbB-2; Tyrosine kinase-type cell surface receptor HER2; p185erbB2; CD antigen CD340)

• Gene ID (Human) :

  2064