CaVα2δ2 rabbit pAb

• Background :

  Calcium voltage-gated channel auxiliary subunit alpha2delta 2 (CACNA2D2) Homo sapiens Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to

• Description :

  Calcium voltage-gated channel auxiliary subunit alpha2delta 2 (CACNA2D2) Homo sapiens Calcium channels mediate the entry of calcium ions into the cell upon membrane polarization. This gene encodes the alpha-2/delta subunit of the voltage-dependent calcium channel complex. The complex consists of the main channel-forming subunit alpha-1, and auxiliary subunits alpha-2/delta, beta, and gamma. The auxiliary subunits function in the assembly and membrane localization of the complex, and modulate calcium currents and channel activation/inactivation kinetics. The subunit encoded by this gene undergoes post-translational cleavage to yield the extracellular alpha2 peptide and a membrane-anchored delta polypeptide. This subunit is a receptor for the antiepileptic drug, gabapentin. Mutations in this gene are associated with early infantile epileptic encephalopathy. Single nucleotide polymorphisms in this gene are correlated with increased sensitivity to

• UniProt :

  Q9NY47

• Swiss Prot :

  Q9NY47

• Reactivity :

  Human; Rat; Mouse

• Immunogen :

  Synthetic Peptide of CaVα2δ2 AA range: 540-620

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; IHC; IF

• Concentration :

  1 mg/ml

• Dilution :

  Western Blot: 1/500 - 1/2000. Immunohistochemistry: 1/100 - 1/300. ELISA: 1/40000. Not yet tested in other applications.

• Molecular Weight :

  100-120kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  100-120kD

• Fragment :

  IgG

• Subcellular Location :

  Membrane ; Single-pass type I membrane protein . Colocalizes with CACNA1A in lipid raft fractions. .

• Other Product Names :

  Voltage-dependent calcium channel subunit alpha-2/delta-2 (Voltage-gated calcium channel subunit alpha-2/delta-2) [Cleaved into: Voltage-dependent calcium channel subunit alpha-2-2; Voltage-dependent calcium channel subunit delta-2]

• Gene ID (Human) :

  9254