MLKL (phospho Ser358) rabbit pAb

• Background :

  This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF) -induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]

• Description :

  This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015],

• Product Name Alternative :

  Mixed lineage kinase domain-like protein

• UniProt :

  Q8NB16

• Swiss Prot :

  Q8NB16

• Reactivity :

  Human

• Immunogen :

  Synthesized peptide derived from human MLKL (phospho S358)

• Target :

  MLKL

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  IHC; IF; WB

• Concentration :

  1 mg/ml

• Dilution :

  IHC-p 1:100-500; IF/ICC 1:100-500; WB 1:500-2000

• Buffer :

  -20°C/1 year

• Molecular Weight :

  55kD

• Storage Conditions :

  -20°C/1 year

• Observed Molecular Weight :

  55kD

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm . Cell membrane . Nucleus . Localizes to the cytoplasm and translocates to the plasma membrane on necroptosis induction (PubMed:24316671) . Localizes to the nucleus in response to orthomyxoviruses infection (By similarity) . .

• Other Product Names :

  Mixed lineage kinase domain-like protein

• Gene ID (Human) :

  197259