MLK3 (Phospho Thr277+Ser281) rabbit pAb

• Background :

  The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008]

• Description :

  The protein encoded by this gene is a member of the serine/threonine kinase family. This kinase contains a SH3 domain and a leucine zipper-basic motif. This kinase preferentially activates MAPK8/JNK kinase, and functions as a positive regulator of JNK signaling pathway. This kinase can directly phosphorylate, and activates IkappaB kinase alpha and beta, and is found to be involved in the transcription activity of NF-kappaB mediated by Rho family GTPases and CDC42. [provided by RefSeq, Jul 2008],

• UniProt :

  Q16584

• Swiss Prot :

  Q16584

• Reactivity :

  Human; Mouse; Rat

• Immunogen :

  Synthesized peptide derived from human MLK3 (Phospho Thr277+Ser281)

• Clonality :

  Polyclonal

• Source :

  Rabbit

• Applications :

  WB; ELISA; IHC

• Concentration :

  1 mg/ml

• Dilution :

  WB 1:500-2000; IHC-p 1:50-300; ELISA 2000-20000

• Storage Conditions :

  -20°C/1 year

• Fragment :

  IgG

• Subcellular Location :

  Cytoplasm, cytoskeleton, microtubule organizing center, centrosome . Location is cell cycle dependent.

• Other Product Names :

  Mitogen-activated protein kinase kinase kinase 11 (EC 2.7.11.25; Mixed lineage kinase 3; Src-homology 3 domain-containing proline-rich kinase)

• Gene ID (Human) :

  4296